Dr Ken Romeo - Anti Aging - Promoting Genetic Stability with Food - Reno Nevada

OPINION:  Dr Ken Romeo   775-870-6942

Genomic instability and genetic alterations are characteristics shared by cancer, aging and other disease states.

Sirtuins (SIRTs) are substances that regulate gene expression in cellular metabolic status.

SIRTs can modulate chromatin function through direct deacetylation of histones and by promoting altered methylation of histones and DNA, leading to repression of gene alteration. This concept is critical.

SIRTs also interact with a broad range of regulators and target gene expression both positively and negatively.

SIRT inhibition may be beneficial in decreasing the risk of some cancers, while SIRT activation can exert positive anti aging effects and help prevent age-related disease and cancers.

Thus, SIRT modulation may positively affect the treatment of cancer and age-related disorders.

The study indicated below reviewed the emerging data regarding SIRTs in cancer and aging. The study found SIRTs to be an important regulator of genomic stability.

We are providing this data ahead of publication in DNA Cell Biology.

The Ten Most Common Sirtuin (SIRTs) Food: (Source: Wikipedia)*

• Green Tea.
• Dark chocolate (that is at least 85 per cent cocoa)
• Apples.
• Citrus fruits.
• Parsley.
• Turmeric.
• Kale.
• Blueberries.
• Red Wine.*
• Capers.

Source: DNA Cell Biol. 2016 Jul 5 (Ahead of publication)

Yours in Health!

Dr. Ken Romeo

Dr. Ken Romeo is a Principal and Chief Clinical Data Coordinator for the Healthy Aging Research Foundation (HARF) in Reno, NV.

Though each article contained on this Blog is derived from published Clinical and Research data contained in various national and international databases with links provided,

NO ARTICLE OR CONCLUSION IS MEANT TO DIAGNOSE, TREAT, PREVENT OR CURE DISEASE.

CONSULT YOUR HEALTH PROFESSIONAL BEFORE MAKING ANY CHANGES TO YOUR HEALTH REGIMEN.

 * The HARF does not recommend the regular consumption of alcoholic beverages.

Contact: DrKenRomeo1@yahoo.com

Dr Ken Romeo - Anti Aging - A DNA Toxic break May Contribute to Accelerated Aging and Disease - Reno Nevada

OPINION:  Dr Ken Romeo   775-870-6942

"DNA double-strand breaks are rare, highly toxic, lesions requiring orchestrated and conserved machinery to prevent adverse consequences, such as cell death and cancer-causing genome structural mutations."

Double strand breaks trigger the DNA damage response that directs a cell to repair the break or begin apoptosis.

There is a probability that double strand breaks are major drivers of intrinsic aging. A model was presented in Mol Cell. 2016 Sep 1;63(5):729-38. doi: 10.1016/j.molcel.2016.08.004., as to how double strand breaks could drive some of the basic mechanisms underlying age-related functional decline and death.

Dr. Ken Romeo is a Principal and Chief Clinical Data Coordinator for the Healthy Aging Research and Genomic Council (HARGC) in Reno, NV.

Though each article contained on this Blog is derived from published Clinical and Research data contained in various national and international databases with links provided,

NO ARTICLE OR CONCLUSION IS MEANT TO DIAGNOSE, TREAT, PREVENT OR CURE DISEASE.

CONSULT YOUR HEALTH PROFESSIONAL BEFORE MAKING ANY CHANGES TO YOUR HEALTH REGIMEN.

 Source: http://www.ncbi.nlm.nih.gov/pubmed/27588601 

CONTACT: DrKenRomeo1@yahoo.com   775-870-6942

Boosting Stem Cells and Saving DNA Naturally - Anti Aging - Reno Nevada - Dr Ken Romeo

OPINION: Dr. Ken Romeo   775-870-6942

Photo by Don Saban. www.DonSaban.com

Our bodies have evolved at the subcellular level to not only sense but fight DNA damage. What's more, our bodies respond in such a way as to repair DNA damage and/or kill the compromised cell if it is damaged too extensively - this process is accomplished through microRNAs.

MicroRNAs play a critical role in the bodies response to DNA damage and the good news is that science is now able to analyze microRNA pathways.

But what, if anything, can we do to help the microRNAs perform their life saving tasks?

Dietary intervention is a potential solution. Foods that contain epigallocatechin-3-gallate like green tea, apple skin, plums, onions, hazelnuts and pecans could help. Also curcumin and resveratrol contain properties that can boost microRNA levels.

The problem is that when food or tea are taken orally in normal amounts the bioavailability of epigallocatechin-3-gallate is small. A person would have to drink between 8-16 cups of green tea daily to have any effect. Drinking this amount of green tea could cause mild side effects such as nausea or heartburn.

For what it's worth, epigallocatechin-3-gallate blood levels peak in approximately 1.7 hours and are then excreted in the urine over a period of 3-15 hours.

The best bet to help microRNAs do their job is probably nutraceutical supplementation with green tea extract, curcumin and/or resveratrol. Also, some specific fatty acids affect microRNA.

Specific pathways, such as fatty acids biosynthesis/metabolism, extracellular matrix-receptor interaction and signaling regulating the pluripotency of stem cells (an immature stem cell capable of giving rise to several different types of cells), appear to be targeted by most microRNAs.

Since DNA damage and DNA repair are strongly related to aging, anti-aging and carcinogenesis, supplementation with nutraceuticals and foods that feed microRNA may be a necessary component to a solid anti-aging and chemopreventive program.

Yours in Health!

Dr. Ken Romeo

Dr. Ken Romeo is a Principal and Chief Clinical Data Coordinator for the Healthy Aging Research Yours in Health!

Foundation (HARF) in Reno, NV.

Though each article contained on this Blog is derived from published Clinical and Research data contained in various national and international databases with links provided,

NO ARTICLE OR CONCLUSION IS MEANT TO DIAGNOSE, TREAT, PREVENT OR CURE DISEASE.

CONSULT YOUR HEALTH PROFESSIONAL BEFORE MAKING ANY CHANGES TO YOUR HEALTH REGIMEN.

Contact: DrKenRomeo1@gmail.com (Reno, NV)